Why some feel very bad with high e2 while others feel better when e2 is on higher end?

Why some men can't tolerate higher e2 levels and swear that would better live with low T rathen then high e2 and others actually feel better when their e2 is highish? What's the reason behind this? I am asking this because I used to be able to tolerate higher e2 and feel great and now it makes me very moody, agitated, no drive/motivation to do anything and low libido.
is it because of aging? or high e2 brings up sickness that was/is masked by low e2?


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