When using a TDEE calculator it is important to use your lean body mass weight instead of your overall body weight when calculating daily protein intake.
Lean body mass refers to the sum of the weight of your bones, muscles and organs. Basically, lean body mass is the sum of everything other than fat in your body.
Be aware that most TDEE calculators (including MyFitnessPal) don't take lean body mass into consideration and therefore could be providing you with wildly inaccurate results.
I strongly suggest that you use a TDEE calculator that incorporate lean body mass into the results. I found a decent one here. Then manually add those results into your MyFitnessPal macros.
You'll often read online or have otherwise been told "rule of thumb" when calculating daily protein intake says the following:
Try and aim for somewhere between ~0.65 to ~1 gram of protein per pound of body weight.
This might be accurate for people who aren't overweight but the "rule of thumb" for most people should be the following:
Try and aim for somewhere between ~0.65 to ~1 gram of protein per pound of lean body mass.
This is especially true if you have a lot of weight to lose.
For example: If I weigh 300 pounds and I intend to lose weight and I follow the (incorrect) rule of thumb that says 1 gram of protein per pound of body weight that would mean I'd be eating 300 grams of protein per day. 300 grams! That's A LOT of protein per day. Not only is it really hard to eat that much (clean) protein everyday, it's a wildly inaccurate amount of daily protein intake and you aren't likely to lose much weight. Instead, if you use your lean body mass (150 pounds) to calculate your daily protein intake you'd end up with half the amount of protein (150 grams) per day which is much more accurate and realistic.
So what does all this mean in relation to your macro-nutrients: protein, carbs and fat? It's important to hit the right "split", that's what percentage of your calories are devoted to each macro-nutrient. A popular split is 40:40:20, that's 40% carbs, 40% protein and 20% fat. That 40% protein is based on your lean body mass weight.
I wish someone would have told me this sooner. Pretty much everyone assumes that people understand this distinction. Lean body mass people! Stick that in your pipe and smoke it. It makes a BIG difference (especially if you are overweight) when calculating caloric intake and macros.
TL;DR: Do not use your overall body weight when calculating your daily protein intake. Instead use your lean body mass weight. Otherwise you could be eating waaaayyyy more calories than you should be eating to lose weight.
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